68

Schroeder, E.A., Toro-Moreno, M., Raphemot, R., Sylvester, K., Colón, I.C., Derbyshire, E.R.** Toxoplasma and Plasmodium Associate with Host Arfs During Infection. mSphere 2024, 9, e00770-23.

67

Mansfield, C.R., Quan, B., Chirgwin, M.E., Eduful, B., Hughes, P.F., Neveu, G., Sylvester, K., Ryan, D.H., Kafsack, B.F.C., Haystead, T.A.J., Leahy, J.W., Fitzgerald, M.C., Derbyshire, E.R.** Selective Targeting of Plasmodium falciparum Hsp90 Disrupts the 26S Proteasome. Cell Chemical Biology 2024, 31, 729-742.

66

Ong, H.W., de Silva, C., Avalani, K., Kwarcinski, F., Mansfield, C.R., Chirgwin, M., Truong, A., Derbyshire, E.R.,** Zutshi, R.,** Drewry, D.** Characterization of 2,4-dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9 and PfPKB. ACS Medicinal Chemistry Letters 2023, 14, 1774-1784.

65

Keeler, A.M., Petruziello, P.E., Boger, E.G., D’Ambrosio, H.K., Derbyshire, E.R.** Exploring the Chain Release Mechanism from an Atypical Apicomplexan Polyketide Synthase. Biochemistry 2023, 62, 2677-2688.

64

Viswanathan, N.K., Chirgwin, M.E., Gibbs, J., Kalaj, B.N., Durham, S., Tran, J., Gomez, M., Lazaro, H., Chen, M., Mansfield, C.R., Derbyshire, E.R., Eagon, S. Synthesis and Activity of β-Carboline Antimalarials Targeting the Plasmodium falciparum Heat Shock 90 Protein. Bioorganic and Medicinal Chemistry Letters 2023, 92, 129410.

63

D’Ambrosio, H.K., Keeler, A.M., Derbyshire, E.R.** Examination of Secondary Metabolite Biosynthesis in Apicomplexa. ChemBioChem 2023, 24, e202300263. Invited Review article.

62

Mansfield, C.R., Chirgwin, M.E., Derbyshire, E.R.** Labeling Strategies to Track Protozoan Parasite Proteome Dynamics. Current Opinion in Chemical Biology 2023, 75, 102316. Invited Review article.

61

Keeler, A.M., D'Ambrosio, H.K., Ganley, J.G., Derbyshire, E.R.** Characterization of Unexpected Self-Acylation Activity of Acyl Carrier Proteins in a Modular Type I Apicomplexan Polyketide Synthase. ACS Chemical Biology 2023, 18, 785-793.

60

Ong, H.W., Truong, A., Kwarcinski, F., de Silva, C., Avalani, K., Havener, T.M., Chirgwin, M.E., Galal, K.A., Willis, C., Krämer, K., Liue, S., Knapp, S., Derbyshire, E.R.**, Zutshi, R.**, Drewry, D.H.** Discovery of Potent Plasmodium falciparum Protein Kinase 6 (PfPK6) Inhibitors with a Type II Inhibitor Pharmacophore. European Journal of Medicinal Chemistry 2023, 249, 115043.

59

Galal, K.A., Truong, A., Kwarcinski, F., de Silva, C., Avalani, K., Havener, T.M., Chirgwin, M.E., Merten, E., Ong, H.W., Willis, C., Abdelwaly, A., Helal, M.A., Derbyshire, E.R.**, Zutshi, R.**, Drewry, D.H.** Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. Journal of Medicinal Chemistry 2022, 65, 13172-13197.

58

Chirgwin, M.E., Schroeder, E.A., Derbyshire, E.R.** Cut it out! A CRISPR-Cas9 Screen Identifies Host Regulators of the Plasmodium Liver Stage. Cell Chemical Biology 2022, 29, 1365-1367. Preview.

57

Tye, M.A., Payne, N.C., Johansson, C., Singh, K., Santos, S.A., Fagbami, L., Pant, A., Sylvester, K., Luth, M.R., Marques, S., Whitman, M., Mota, M.M., Winzeler, E.A., Lukens, A.K., Derbyshire, E.R., Oppermann, U., Wirth, D.F., Mazitschek, R. Elucidating the Path to Plasmodium Prolyl-tRNA Synthetase Inhibitors that Overcome Halofuginone Resistance. Nature Communications 2022, 13, 4976.

56

Mughal, H., Bell, E.C., Mughal, K., Derbyshire, E.R.**, Freundlich, J.S.** Random Forest Model Predictions Afford Dual-Stage Antimalarial Agents. ACS Infectious Diseases 2022, 8, 1553-1562.

55

D’Ambrosio, H.K., Ganley, J.G., Keeler, A.M., Derbyshire, E.R.** A Single Amino Acid Residue Controls Acyltransferase Activity in a Polyketide Synthase from Toxoplasma gondii. iScience 2022, 25, 104443.

54

Schroeder, E.A., Chirgwin, M.E., Derbyshire, E.R.** Plasmodium’s Fight for Survival: Escaping Elimination While Acquiring Nutrients. Trends in Parasitology 2022, 4, 544-557. Invited Review Article.

53

Lu, K.Y., Mansfield, C.R., Fitzgerald, M.C., Derbyshire, E.R.** Chemoproteomics for Plasmodium Parasite Drug Target Discovery. ChemBioChem 2021, 22, 2591–2599. Invited Review Article. Featured on Cover.

52

Sylvester, K., Maher, S.P., Posfai, D., Tran, M.K., Crawford, M.C., Vantaux, A., Witkowski, B., Kyle, D.E., Derbyshire, E.R.** Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts. Frontiers in Cellular and Infection Microbiology 2021, 11, 517.

51

Bang, S., Donnelly, C.R., Toro-Moreno, M., Luo, X., Tao, X., Wang, Z., Chandra, S., Bortsov, A.V., Derbyshire, E.R., and Ji, R.R.** Activation of GPR37 in Macrophages Confers Protection Against Infection-Induced Sepsis and Pain-Like Behaviour in Mice. Nature Communications 2021, 12, 1704.

50

Lu, K.Y., Pasaje, C.F.A., Srivastava, T., Loiselle, D.R., Niles, J.C., Derbyshire, E.R.** Phosphatidylinositol 3-Phosphate and Hsp70 Protect Plasmodium falciparum from Heat-Induced Cell Death. eLife 2020, 9, e56773: Highlighted in news.

49

Ganley, J.G., Pandey, A., Sylvester, K., Lu, K.Y., Toro-Moreno, M., Rütschlin, S., Bradford, J.M., Champion, C.J., Böttcher, T., Xu, J., Derbyshire, E.R.** A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity. Cell Chemical Biology 2020, 27, 817–826.

48

Posfai, D., Maher, S.P., Roesch, C., Vantaux, A., Sylvester, K., Péneau, J., Popovici, J., Kyle, D.E., Witkowski, B.,** Derbyshire, E.R.** Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3. Cell Chemical Biology 2020, 27, 719–727: Recommended in Faculty Opinions.

47

Lu, K.Y., Quan, B., Sylvester, K., Srivastava, T., Fitzgerald, M.C.,** Derbyshire, E.R.** Plasmodium Chaperonin TRiC/CCT Identified as a Target of the Antihistamine Clemastine Using Parallel Chemoproteomic Strategy. Proceedings of the National Academy of Sciences 2020, 117, 5810-5817.

46

Lu, K.Y., Derbyshire, E.R.** Tafenoquine: A Step Toward Malaria Elimination. Biochemistry 2020, 59, 911-920. Invited Review Article.

45

Ganley, J.G., Derbyshire, E.R.** Linking Genes to Molecules in Eukaryotes: An Endeavor to Expand our Enzymatic Repertoire. Molecules 2020, 25, E625. Invited Review Article.

44

Toro-Moreno, M., Derbyshire, E.R.** It’s About Time: Insights into the Modes of Action of Antimalarials. Cell Chemical Biology 2020, 27, 139-141. Invited Insight.

43

Ganley, J.G., D’Ambrosio, H.K., Shieh, M., Derbyshire, E.R.** Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anopheles. ChemBioChem 2020, 21, 1279–1284: Selected as Very Important Paper. Featured on Cover.

42

Toro-Moreno, M., Sylvester, K., Srivastava, T., Posfai, D., Derbyshire, E.R.** RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver Infection. mBio 2020, 11, e03234-19.

41

D’Ambrosio, H.K., Derbyshire, E.R.** Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis. ACS Chemical Biology 2020, 15, 17-27. Invited Review Article.

40

Raphemot, R., Toro-Moreno, M., Lu, K.Y., Posfai, D., Derbyshire, E.R.** Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection. Cell Chemical Biology 2019, 26, 1253-1262: Highlighted in news.

39

Szamosvári, D., Sylvester, K., Schmid, P., Lu, K.Y., Derbyshire, E.R.,** Böttcher, T.** Close the Ring to Break the Cycle: Tandem Quinolone-Alkyne-Cyclisation Gives Access to Tricyclic Pyrrolo[1,2-a]quinolin-5-ones with Potent Anti-Protozoal Activity. Chemical Communications 2019, 55, 7009-7012: Featured on Back Cover.

38

Raphemot, R., Eubanks, A.L., Toro-Moreno, M., Geiger, R., Hughes, P.H., Lu, K.Y., Haystead, T.A., Derbyshire, E.R.** Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chemical Biology 2019, 26, 411-419.

37

Lee, H., Sylvester, K., Derbyshire, E.R., Hong, J. Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions. Chemistry - A European Journal 2019, 25, 6500-6504.

36

Eubanks, A.L., Perkins, M.M., Sylvester, K., Ganley, J.G., Posfai, D., Sanschargrin, P.C., Hong, J., Sliz, P., Derbyshire, E.R.** In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 Inhibitors. ChemMedChem 2018, 13, 2479-2483. Featured in Special Collection on Neglected and Tropical Diseases (2020 Hot Topic Series).

35

Posfai, D., Sylvester, K., Reddy. A., Ganley J.G., Wirth J., Cullen, Q.E., Dave, T., Kato, N., Dave, S.S., Derbyshire, E.R.** Plasmodium Parasite Exploits Host Aquaporin-3 During Liver Stage Malaria Infection. PLOS Pathogens 2018, 14, e1007057: Featured on Cover. Highlighted in news.

34

Ganley, J.G., Carr, G., Ioerger, T.R., Sacchettini, J.C., Clardy, J.,** Derbyshire, E.R.** Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. ChemBioChem 2018, 19, 1590-1594: Selected as Very Important Paper. Featured on Cover.

33

Posfai, D., Eubanks, A.L., Keim, A.I., Lu, K.Y., Wang, G.Z., Hughes, P.F., Kato, N., Haystead, T.A., Derbyshire, E.R.** Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrobial Agents and Chemotherapy 2018, 62, e01799-17.

32

Ganley, J.G., Toro-Moreno, M., Derbyshire, E.R.** Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites. Biochemistry 2018, 57, 365-375. Invited Review Article.

31

Totzke, J., Gurbani, D., Raphemot, R., Hughes, P.F., Bodoor, K., Carlson, D.A., Eibschutz, L.S., Perkins, M.M., Eubanks, A.L., Campbell, P., Fox, D., Westover, K.**, Haystead, T.A.**, Derbyshire, E.R.** Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chemical Biology 2017, 24, 1029-1039.

30

Kato, N., Comer, E., Sakata-Kato, T., Maetani, M., Bastien, J., Corey, V., Clarke, D., Derbyshire, E.R., Dornan, G., Duffy, S., Eckley, S., Koolen, K.M.J., Lewis, T., Lund, E., Riera, S.M., McPhail, J., Mitasev, B., Moss, E., Sayes, M., VanGessel, Y., Wawer, M., Yoshinaga, T., Zeeman, A., Avery, V.M., Bhatia, S.N., Burke, J.E., Catteruccia, F., Clardy, J., Clemons, P.A., Dechering, F., Duvall, J.R., Foley, M.A., Gusovsky, F., Kocken, C.H., Morningstar, M., Munoz, B., Neafsey, D., Winzeler, E.A., Wirth, D.F., Scherer, C.A., Schreiber, S.L. Diversity-oriented Synthesis Yields Novel Multistage Antimalarial Inhibitors. Nature 2016, 538, 344-349.

29

Raphemot, R., Posfai, D., Derbyshire, E.R.** Current Therapies and Future Possibilities for Novel Antimalarial Drug Development. Journal of Clinical Investigation 2016, 126, 2013-2020.

28

Raphemot, R., Lafuente-Monasterio, M., Gamo, F.J., Clardy, J., Derbyshire, E.R.** Discovery of Dual Stage Malaria Inhibitors with New Targets. Antimicrobial Agents and Chemotherapy 2016, 60, 1430-1437. Invited Review Article.

27

Derbyshire, E.R.**, Zuzarte-Luís, V., Magalhães, A.D., Kato, N., Sanschagrin, P.C., Wang, J., Zhou, W., Miduturu, C.V., Mazitschek, R., Sliz, P., Mota, M.M., Gray, N.S., Clardy, J.** Chemical Interrogation of the Malarial Host and Parasite Kinomes. ChemBioChem 2014, 15, 1920-1930: Featured on Cover.

26

Derbyshire, E.R.**, Min, J., Guiguemde, W.A., Clark, J.A., Connelly, M.C., Magalhães, A.D., Guy, R.K., Clardy, J.** Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites. Antimicrobial Agents and Chemotherapy 2014, 58, 1516-1522.

25

Herman, J.D., Pepper, L.R., Cortese, J.F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E.R., Ribacke, U., Lukens, A.K., Santos, S.A., Patel, V., Clish, C.B., Sullivan, W.J. Jr, Zhou, H., Bopp, S.E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M.M., Keller, T.L., Whitman, M., Wiest, O., Wirth, D.F., Mazitschek, R. The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target of Febrifugine and its Analogs. Science Translational Medicine 2015, 7, 288ra77.

24

Derbyshire, E.R., Clardy, J. Closing in on a New Treatment for Sleeping Sickness. eLife 2013, 2, e01042. Insight.

23

Carr, G., Derbyshire, E.R., Caldera, E., Currie, C.R., Clardy, J. Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. Journal of Natural Products 2012, 75, 1806-1809.

22

Gunn, A., Derbyshire, E.R., Marletta, M.A., Britt, R.D. Conformationally Distinct Five-Coordinate Heme-NO Complexes of Soluble Guanylate Cyclase Elucidated by Multifrequency EPR. Biochemistry 2012, 51, 8384-8390.

21

Fernhoff, N.B., Derbyshire, E.R., Underbakke E.S., Marletta, M.A. Heme-Assisted S-nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide. Journal of Biological Chemistry 2012, 287, 43053-43062.

20

Derbyshire, E.R., Mazitschek, R., Clardy, J. Characterization of Plasmodium Liver Stage Inhibition by Halofuginone. ChemMedChem 2012, 7, 844-849: Selected as Very Important Paper. Featured on Cover.

19

Derbyshire, E.R., Prudencio, M., Mota, M.M., Clardy, J. Liver-Stage Malaria Parasites Vulnerable to Diverse Chemical Scaffolds. Proceedings of the National Academy of Sciences 2012, 109, 8511-8516.

18

Derbyshire, E.R., Marletta, M.A. Structure and Regulation of Soluble Guanylate Cyclase. Annual Review in Biochemistry 2012, 81, 533-539.

17

Dong, C.K., Urgaonkar, S., Cortese, J.F., Gamo, F.J., Garcia-Bustos, J.F., Lafuente, M.J., Patel, V., Ross, L., Coleman, B.I., Derbyshire, E.R., Clish, C.B., Serrano, A.E., Cromwell, M., Barker, R.H. Jr, Dvorin, J.D., Duraisingh, M.T., Wirth, D.F., Clardy, J., Mazitschek, R. Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors. Chemistry & Biology 2011, 18, 1602-1610.

16

Derbyshire, E.R., Mota, M.M., Clardy, J. The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage. PLoS Pathogens 2011, 7, e1002178.

15

Derbyshire, E.R., Winter, M.B., Ibrahim, M., Deng, S., Spiro, T.G., Marletta, M.A. Probing Domain Function in Soluble Guanylate Cyclase. Biochemistry 2011, 50, 4281-4290: Featured article.

14

Ibrahim, M., Derbyshire, E.R., Soldatova, A.V., Marletta, M.A., Spiro, T.G. Soluble Guanylate Cyclase Is Activated Differently by Excess NO and by YC-1: Resonance Raman Spectroscopic Evidence. Biochemistry 2010, 49, 4864-4871.

13

Ibrahim, M., Derbyshire, E.R., Marletta, M.A., Spiro, T.G. Probing Soluble Guanylate Cyclase Activation by CO and YC-1 Using Resonance Raman Spectroscopy. Biochemistry 2010, 49, 3815-3823.

12

Derbyshire, E.R., Deng, S., Marletta, M.A. Incorporation of Tyrosine and Glutamine Residues into the Soluble Guanylate Cyclase Heme Distal Pocket Alters NO and O2 Binding. Journal of Biological Chemistry 2010, 285, 17471-17478.

11

Fernhoff, N.B., Derbyshire, E.R., Marletta, M.A. A Nitric Oxide/Cysteine Interaction Mediates the Activation of Soluble Guanylate Cyclase. Proceedings of the National Academy of Sciences 2009, 106, 21602-21607.

10

Derbyshire, E.R., Fernhoff, N.B., Deng, S., Marletta, M.A. Nucleotide Regulation of Soluble Guanylate Cyclase Substrate Specificity. Biochemistry 2009, 48, 7519-7524.

9

Derbyshire, E.R., Marletta, M.A. Biochemistry of Soluble Guanylate Cyclase. Handbook of Experimental Pharmacology 2009, 191, 17-31. Book chapter.

8

Winger, J.A., Derbyshire, E.R., Lamers, M.H., Marletta, M.A., Kuriyan, J. The Crystal Structure of the Catalytic Domain of a Eukaryotic Guanylate Cyclase. BMC Structural Biology 2008, 8, 42: Highly accessed article.

7

Derbyshire, E.R., Gunn, A., Ibrahim, M., Spiro, T.G., Britt, R.D., Marletta, M.A. Characterization of Two Different 5-Coordinate Soluble Guanylate Cyclase Ferrous Nitrosyl Complexes. Biochemistry 2008, 47, 3892-3899.

6

Derbyshire, E.R., Marletta, M.A. Nitric Oxide: Biological Targets. Wiley Encyclopedia of Chemical Biology 2008, 4, 1-8. Book chapter.

5

Derbyshire, E.R., Marletta, M.A. Butyl Isocyanide as a Probe of the Activation Mechanism of Soluble Guanylate Cyclase: Investigating the Role of Non-Heme Nitric Oxide. Journal of Biological Chemistry 2007, 282, 35741-35748.

4

Martin, N.I., Derbyshire, E.R., Marletta, M.A. Synthesis and Evaluation of a Phosphonate Analogue of the Soluble Guanylate Cyclase Activator YC-1. Bioorganic and Medicinal Chemistry Letters 2007, 17, 4938-4941.

3

Winger, J.A., Derbyshire, E.R., Marletta, M.A. Dissociation of Nitric Oxide from Soluble Guanylate Cyclase and H-NOX Domain Constructs. Journal of Biological Chemistry 2006, 282, 897-907.

2

Cary, S.P.L., Winger, J.A., Derbyshire, E.R., Marletta, M.A. Nitric Oxide Signaling: No Longer Simply On or Off. Trends in Biochemical Sciences 2006, 31, 231-239.

1

Derbyshire, E.R., Tran, R., Mathies, R., Marletta, M.A. Characterization of Nitrosoalkane Binding and Activation of Soluble Guanylate Cyclase. Biochemistry 2005, 49, 16257-16265.