Publications

Posfai, D., Eubanks, A.L., Keim, A.I., Lu, K.Y., Wang, G.Z., Hughes, P.F., Kato, N., Haystead, T.A., Derbyshire, E.R.** Identification of Hsp90 Inhibitors with anti-Plasmodium Activity. Antimicrobial Agents and Chemotherapy 2018, Accepted.
Ganley, J.G., Toro-Moreno, M., Derbyshire, E.R.** Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites. Biochemistry 2018, Accepted.
Totzke, J., Gurbani, D., Raphemot, R., Hughes, P.F., Bodoor, K., Carlson, D.A., Eibschutz, L.S., Perkins, M.P., Eubanks, A.L., Campbell, P., Fox, D., Westover, K.,** Haystead, T.A.,** Derbyshire, E.R.** Takinib, an Exquisitely Selective Inhibitor of TAK1, Targets Pro Survival TNFa- Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Cell Models. Cell Chemical Biology 2017, 24, 1029-1039.
Kato, N., Comer, E., Sakata-Kato, T., Maetani, M., Bastien, J., Corey, V., Clarke, D., Derbyshire, E.R., Dornan, G., Duffy, S., Eckley, S., Koolen, K.M.J., Lewis, T., Lund, E., Riera, S.M., McPhail, J., Mitasev, B., Moss, E., Sayes, M., VanGessel, Y., Wawer, M., Yoshinaga, T., Zeeman, A., Avery, V.M., Bhatia, S.N., Burke, J.E., Catteruccia, F., Clardy, J., Clemons, P.A., Dechering, F., Duvall, J.R., Foley, M.A., Gusovsky, F., Kocken, C.H., Morningstar, M., Munoz, B., Neafsey, D., Winzeler, E.A., Wirth, D.F., Scherer, C.A., Schreiber, S.L. Diversity Synthesis Yields Novel Multistage Antimalarial Inhibitors. Nature 2016, 538, 344-349.
Raphemot, R., Posfai, D., Derbyshire, E.R.** Current Therapies and Future Possibilities for Novel Antimalarial Drug Development. Journal of Clinical Investigation 2016, 126, 2013-2020.
Raphemot, R., Lafuente-Monasterio, M., Gamo, F.J., Clardy, J., Derbyshire, E.R.** Discovery of Dual Stage Malaria Inhibitors with New Targets. Antimicrobial Agents and Chemotherapy 2016, 60, 1430-1437.
Derbyshire, E.R.,** Zuzarte-Luís, V., Magalhães, A.D., Kato, N., Sanschagrin, P.C., Wang, J., Zhou, W., Miduturu, C.V., Mazitschek, R., Sliz, P., Mota, M.M., Gray, N.S., Clardy, J.** Chemical Interrogation of the Malarial Host and Parasite Kinomes. ChemBioChem 2014, 15, 1920-1930. Featured on Cover.
Derbyshire, E.R.,** Min, J., Guiguemde, W.A., Clark, J.A., Connelly, M.C., Magalhães, A.D., Guy, R.K., Clardy, J.** Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites. Antimicrobial Agents and Chemotherapy 2014, 58, 1516-1522.

**Corresponding author.

Postdoctoral and graduate publications:

Herman, J.D., Pepper, L.R., Cortese, J.F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E.R., Ribacke, U., Lukens, A.K., Santos, S.A., Patel, V., Clish, C.B., Sullivan, W.J. Jr, Zhou, H., Bopp, S.E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M.M., Keller, T.L., Whitman, M., Wiest, O., Wirth, D.F., Mazitschek, R. The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target of Febrifugine and its Analogs. Science Translational Medicine 2015, 7, 288ra77.
Derbyshire, E.R., Clardy, J. Closing in on a New Treatment for Sleeping Sickness. eLife 2013, 2, e01042. Insight.
Carr, G., Derbyshire, E.R., Caldera, E., Currie, C.R., Clardy, J. Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. Journal of Natural Products 2012, 75, 1806-1809.
Gunn, A., Derbyshire, E.R., Marletta, M.A., Britt, R.D. Conformationally Distinct Five-Coordinate Heme-NO Complexes of Soluble Guanylate Cyclase Elucidated by Multifrequency EPR. Biochemistry 2012, 51, 8384-8390.
Fernhoff, N.B., Derbyshire, E.R., Underbakke E.S., Marletta, M.A. Heme-Assisted S-nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide. Journal of Biological Chemistry 2012, 287, 43053-43062.
Derbyshire, E.R., Mazitschek, R., Clardy, J. Halofuginone Inhibition of Liver Stage Malaria. ChemMedChem 2012, 7, 844-849: Selected as Very Important Paper. Featured on Cover.
Derbyshire, E.R., Prudencio, M., Mota, M.M., Clardy, J. Liver-Stage Malaria Parasites Vulnerable to Diverse Chemical Scaffolds. Proceedings of the National Academy Science 2012, 109, 8511-8516.
Derbyshire, E.R., Marletta, M.A. Structure and Regulation of Soluble Guanylate Cyclase. Annual Review in Biochemistry 2012, 81, 533-539. Review article.
Dong, C.K., Urgaonkar, S., Cortese, J.F., Gamo, F.J., Garcia-Bustos, J.F., Lafuente, M.J., Patel, V., Ross, L., Coleman, B.I., Derbyshire, E.R., Clish, C.B., Serrano, A.E., Cromwell, M., Barker, R.H. Jr, Dvorin, J.D., Duraisingh, M.T., Wirth, D.F., Clardy, J., Mazitschek, R. Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors. Chemistry & Biology 2011, 18, 1602-1610.
Derbyshire, E.R., Mota, M.M., Clardy, J. The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage. PLoS Pathogens 2011, 7, e1002178. Review article.
Derbyshire, E.R., Winter, M.B.,* Ibrahim, M.,* Deng, S., Spiro, T.G., Marletta, M.A. Probing Domain Function in Soluble Guanylate Cyclase. Biochemistry 2011, 50, 4281-4290: Featured article.
Ibrahim, M., Derbyshire, E.R., Soldatova, A.V., Marletta, M.A., Spiro, T.G. Soluble Guanylate Gyclase is Activated Differently by Excess NO and YC-1: Resonance Raman Spectroscopic Evidence. Biochemistry 2010, 49, 4864-4871.
Ibrahim, M., Derbyshire, E.R., Marletta, M.A., Spiro, T.G. Probing Soluble Guanylate Cyclase Activation by CO and YC-1 Using Resonance Raman Spectroscopy. Biochemistry 2010, 49, 3815-3823.
Derbyshire, E.R., Deng, S., Marletta, M.A. Incorporation of Tyrosine and Glutamine Residues into the Soluble Guanylate Cyclase Heme Distal Pocket Alters NO and O2 Binding. Journal of Biological Chemistry 2010, 285, 17471-17478.
Fernhoff, N.B.,* Derbyshire, E.R.,* Marletta, M.A. A Nitric Oxide/Cysteine Interaction Mediates the Activation of Soluble Guanylate Cyclase. Proceedings of the National Academy Science 2009, 106, 21602-21607.
Derbyshire, E.R., Fernhoff, N.B., Deng, S., Marletta, M.A. Nucleotide Regulation of Soluble Guanylate Cyclase Substrate Specificity. Biochemistry 2009, 48, 7519-7524.
Derbyshire, E.R., Marletta, M.A. Biochemistry of Soluble Guanylate Cyclase. Handbook of Experimental Pharmacology 2009, 191, 17-31. Book chapter.
Winger, J.A., Derbyshire, E.R., Lamers, M.H., Marletta, M.A., Kuriyan, J. The Crystal Structure of the Catalytic Domain of a Eukaryotic Guanylate Cyclase. BMC Structural Biology 2008, 8, 42: Highly accessed article.
Derbyshire, E.R., Gunn, A., Ibrahim, M., Spiro, T.G., Britt, R.D., Marletta, M.A. Characterization of Two Different 5-Coordinate Soluble Guanylate Cyclase Ferrous Nitrosyl Complexes. Biochemistry 2008, 47, 3892-3899.
Derbyshire, E.R., Marletta, M.A. Nitric Oxide: Biological Targets. Wiley Encyclopedia of Chemical Biology 2008, 4, 1-8. Book chapter.
Derbyshire, E.R., Marletta, M.A. Butyl Isocyanide as a Probe of the Activation Mechanism of Soluble Guanylate Cyclase: Investigating the Role of Non-Heme Nitric Oxide. Journal of Biological Chemistry 2007, 282, 35741-35748.
Martin, N.I., Derbyshire, E.R., Marletta, M.A. Synthesis and Evaluation of a Phosphonate Analogue of the Soluble Guanylate Cyclase Activator YC-1. Bioorganic and Medicinal Chemistry Letters 2007, 17, 4938-4941.
Winger, J.A.,* Derbyshire, E.R.,* Marletta, M.A. Dissociation of Nitric Oxide from Soluble Guanylate Cyclase and H-NOX Domain Constructs. Journal of Biological Chemistry 2006, 282, 897-907.
Cary, S.P.L., Winger, J.A., Derbyshire, E.R., Marletta, M.A. Nitric Oxide Signaling: No Longer Simply On or Off. Trends in Biochemical Sciences 2006, 31, 231-239. Review article.
Derbyshire, E.R., Tran, R., Mathies, R., Marletta, M.A. Characterization of Nitrosoalkane Binding and Activation of Soluble Guanylate Cyclase. Biochemistry 2005, 49, 16257-16265.

*These authors contributed equally.