The Derbyshire Lab

Duke University

Departments of Chemistry,

Molecular Genetics and Microbiology,

and Cell Biology

Welcome to the Derbyshire Lab, a collaborative, multidisciplinary research group that works at the interface of chemistry and biology to address global health problems.

We are committed to fostering a culture of respect, professionalism, and opportunity. We value the experiences and perspectives that each individual brings, as they contribute to our shared success and innovation.

Research Overview

Chemical Biology

Biochemistry - Enzymology

Image of mosquito salivary gland with GFP parasites by Dr. Dora Posfai, Duke University

Microbiology - Parasitology

Parasites infect billions of humans each year and cause several major diseases, largely in underserved populations in developing parts of the world. Malaria, in particular, is a leading cause of deaths worldwide, and its causative agents, Plasmodium parasites, are crafty as they have successfully eluded our defense mechanisms since they first infected us tens of thousands of years ago.

The Derbyshire Lab uses chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens – forward and reverse chemical genetics – to dissecting biological pathways and identifying small molecules with potential therapeutic value. Our interdisciplinary collaborative program integrates both novel and established methods to address target identification, which is one of the most challenging aspects of malaria drug discovery. Our lab’s goal is to globally interrogate parasite biology by using chemical biology, molecular biology, biochemistry and parasitology.

GFP parasite transformation in a liver cell
Dr. Dora Posfai, Duke University

Latest Publications

Host sphingolipids support Plasmodium berghei liver stage development

Schroeder, E.A., Colón, I.C., Petruziello, P.E., Derbyshire, E.R.** Host Sphingolipids Support Plasmodium berghei Liver Stage Development. mBio 2025 16, e0167525.

Covalent inhibition of Plasmodium falciparum Ubc13 impairs global protein synthesis

Truong, A., Hu, R., Quan, B., Bailey, M.A., Schroeder, E.A., Sylvester, K., Neveu, G., Kafsack, B.F.C., Fitzgerald, M.C., Derbyshire, E.R.** Covalent Inhibition of Plasmodium falciparum Ubc13 Reveals Translational Control by K63-Ubiquitin. iScience 2025, 28, 112545.

Selective Targeting of Plasmodium falciparum Hsp90 Disrupts the 26S Proteasome

Mansfield, C.R., Quan, B., Chirgwin, M.E., Eduful, B., Hughes, P.F., Neveu, G., Sylvester, K., Ryan, D.H., Kafsack, B.F.C., Haystead, T.A.J., Leahy, J.W., Fitzgerald, M.C., Derbyshire, E.R. Selective Targeting of Plasmodium falciparum Hsp90 Disrupts the 26S Proteasome. Cell Chemical Biology 2024, 31, 729-742.

Characterization of 2,4-dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9 and PfPKB

Ong, H.W., de Silva, C., Avalani, K., Kwarcinski, F., Mansfield, C.R., Chirgwin, M., Truong, A., Derbyshire, E.R.,** Zutshi, R.,** Drewry, D.** Characterization of 2,4-dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9 and PfPKB. ACS Medicinal Chemistry Letters 2023, 14, 1774-1784.